Well if it is a challenge your after.. Don't go for Blacksmithing or Enchanting, only go for Alchemy.. Play a warrior character (Personaly i use a sword and board, tried two handed first with my playstyle but it was to compromised and i died really easy). Don't use magical equipment. Of course if you loot a weapon with a magical property, with higher base damage.. I would use it and not recharge it when its empty.. This makes the game grand fun

And keeps me playing on Adept. I tried the harder modes but thats insane (atleast for me)

So in short my playstyle is;
1) No magical equipment except looted (Dont recharge when empty)
2) No healing spells
3) Use of only clairvoyance spell
4) No enchanting/smithing
Thats one way to get a challenge, without making things complicated..