When fighting against enemies in very close quarters, 95% in V.A.T.S. is a sure miss. It's possible that this only happens when the enemy is on the ground level.

The game also has issues detecting obstacles in Vault-Tec Assisted Targeting System, it can show a positive percentage when the target is behind a pillar etc.

Example (it isn't possible to get a hit): https://onedrive.live.com/redir?resid=130B665BF39DFD1!4439&authkey=!AM6N_yIXHlIpeCI&v=3&ithint=photo%2Cpng

I have noticed this problem from time to time. Especially with headshots against Nightstalkers, like in your photo.

Is this only a problem with ranged weapons? I don't use melee weapons very often, but I seem to remember in Dead Money using knives in V.A.T.S. at close quarters, successfully.

This is definitely a fault with the ranged weapon VAT attacks. It happens to me most all of the time. I have to carefully time it so that my opponent is still a step or two away before firing otherwise I'll waste some very valuable ammunition.

Rabbit