My latest character (3rd play-through) I envisioned as a sort of former pre-war black-hat hacker that was roped into serving with the military to stay out of prison. Anyway I figured his favorite weapon would be the 10mm pistol and that he would also be a bit of a handgun nut/expert.
So now at level 45 he still only uses handguns but he has three that he cycles through depending on range and how bad the enemy is.
10mm
Laser Pistol
Plasma Pistol
But I tell ya I just ENJOY using the 10mm more! I love the visual, the sound... all of it. I also don't like the ash piles and goo piles left behind by the other two...from what I have read they potentially could cause save file problems when they reach a certain extreme number. So I find myself "cleaning up" via console commands and that's kind of a pain.
So I think I'll just build me a long range 10mm (with better optics and longer barrel) and continue using stealth and my standard barreled glow-sighted 10mm as primary. Withe the right perks (and luck) I think the 10mm could be viable all the way through.