There are 95 perks listed in this thread: http://www.gamesas.com/index.php?/topic/1233644-sammus-eurogamer-qa/
So if there are officially 220 unique ones, it's nice to know that those listed there aren't even half of what's available.
Btw, how many unique spells are there in Skyrim?
That's 95 for 12 skills, Smithing has 10, pick pockets 8 without ranks, blade has 8, block has 9, so that's 130 without lock picking and light armour, and we know there are more Alteration perks, so looks to be about 150 unique perks.