I think it would be better if you have to drink once a day and eat/sleep every two days.
Some might argue that that's the point to a hardcoe mode, but if you wanna be really hardcoe than why not just make the player eat but also make them eat healthy and have them sleep at least 5-6 hours in the game. This would also be realistic yet incredibly boring. Stimpaks healing over time and needing a doctor's bag or high enough medicine skill to heal crippled limbs, and ammo having weight are all great things to make the game more challenging. And this was also so in FO1&2, but you have to be careful not to make these new drink/eat/sleep requirements too harsh because having to do all three things every 45min in game will become very annoying very fast.
I hope that we can get some clarification from a dev on this real soon
