As tempting as it is to sell everything you collect, hold off on it. Running quest lines will give you enough gold to play with in the beginning. Use the materials you find/loot/harvest and make use it for your own crafting. If you have materials that aren't for what you craft, try trading your unneeded crafting materials with others for what you do need.
Harvest EVERY node you can. Breaking those down not only give you a great amount of crafting materials, you also gain items that give you a chance to improve your items your making.
Sacrifice armor and weapons early on in the game to learn off of (In crafting). You lose out on the item, but you learn the items skill early and it becomes a great help.
Leveling with a group makes leveling much quicker due to quests, and you gain more money and use less resources.
Snakes/Spiders/Rats/Lightning bugs all give you fishing bait.
When opening chests, let go of your mouse right before the lock jiggles. Any later and you have to start over of you break your lock pick.
Whenever your screen locks up in a dialog, type /reloadui. As a matter of fact, when anything funny happens, type /reloadui. Fixes most issues.