Just a thought...
I'd like to see an affect from drinking booze and taking skooma.
when you drink evrything could go a little wobbly and maybe you'd fall over.
skooma you could slow down time a few milliseconds, not so it afects just so you feel al little faster. it could make you focus on things closer and further away items would be blurry.
i don't know what do yall think?

I originally typed up a post saying this was a bad idea, but I kind of agree now after thinking about it.
If I drink a lot of beer and walk into a sword fight, I'd like to see my character sort of fumble to draw his sword, then have a drunken stance. If I've had too much, maybe fall over similar to what you'd do with completely drained fatigue.

As for skooma, I would be annoyed with the slowed time. Just enhanced strength with a negative effect on intelligence, then when you go through withdrawals the vision blurs or your character is naturally weaker because he/she is dependent on skooma.

How about some drunken fist kungfu?

i'm not sure what skooma is suposed to do, but if its anything like meth-amphetimines then it would be like slowing time. not so much as evreybody is moving slow-mo just so it's lik your moving the tiniest bit faster than them. i relate it to meth as in morrowind i remember some off-chops guy in the sewer trying to kill me, being jacked off his head. meth is usually considered a very violent drug, much like crack cocaine is in america.
and the effects..... well.... a friend told me.

I'd be pretty funny if they made some crazy stuff like wild wasteland in fallout, but you could only see it while you were on skooma.