Not quests mind you, but you go back to level one and all the perks are gone and all the map locations have been erased from your pip boy.
You would have to explore the wasteland and rediscover all these places. You could call the perk Amnesia and once you take it your immediately knocked out and you awake outside Sanctuary Hills Naked and all your stuff gone.
I’m sure there needs to be more detail to it but this could be fun. I don’t know how settlements would be doing this.