Have you enhanced the package system that Oblivion/Fo3/Nv used to control all of the NPC's ingame? Have you improved it along with adding the radiant story?
What will the currency be?
Can you still block if you have a weapon combination like Sword/Spell, Sword/Sword, etc?
Is the game build from large interior chunks (Oblivion), or many small tile pieces (Fallout 3/Nv), allowing for more unique shapes?
Have you guys gotten more creative with using objects in an untraditional manner? There is SO little of this in Fallout 3/NV and Oblivion. I mean like, how the Cube Experimental mod used the default pieces in really creative ways to make crazy looking stuff. Or would you guys just rather have a modeller build you something to use in one piece?
Will there be better NPC reaction to the player if they are walking through a town while: Almost dead/severely wounded, naked, covered in blood, dragging a body, etc.?