I love all these suggestions to minmax for EWs and beeline straight towards the Uniques...
Do you have to do this to keep up to snuff with Guns?
More or less, unless the upcoming patch put an Recharger pistol in Mitchel's house instead of Laser Pistol and buff them like:
Laser Pistol roughly on level with 10mm
Plasma Pistol between .357 and .44
Plasma Defender roughly as powerful as 12.7mm Pistol