When playing through Fallout New Vegas (non-Ultimate Edition) the first time, I remember hearing about big problems with the "Come Fly With Me" quest, so I held onto a save before entering REPCONN, and rotated the other saves. As it happens, I had no problems at all.

Now I'm playing the Ultimate Edition, and I'll hold onto a save before "Come Fly With Me" again, just in case, and I'm also holding onto one save before entering each DLC. Are there any other quests and/or locations where I should be holding onto a save before starting/entering them?

Also, while I'm here, I chose the Wild Wasteland perk for the hell of it this time around. I had a look on the Wiki, and it seems that there are quite a few occurrences at particular locations. Does anyone know if these locations are marked on your map when you have the Explorer perk, or if they show up on the compass? Or am I going to have to find a map of the locations online so I can make sure I make the most of the perk?

The problem quests vary from game to game. If you want a list of *potential problem quests I would wiki it.

As for the WW, no there are no map markers showing where they happen. Just have to take them as they come. It's better when you get hit with it unexpectedly rather than hunting them down as they aren't that impressive.

But it does seem like some of the WW locations are quite off the beaten track though, and could therefore be missed easily. I always visit every location in the Fallout games, but I wouldn't say I walk every square inch of the wasteland.

Maybe I'll just play it as normal, and if I find them I find them.

The late-main-quest mission in Hoover Dam doesn't work properly for me anymore (You Know When It Happens). I can complete it the way i want, but not without consulting the wiki.

Which is weird, because i remember it working correctly earlier Did a patch break it, or what?

Huh? i've never had a problem with the come fly with me quest. And i've done it dozens of times.

Apparently lots of people had a a corrupt save problem during the quest, and sometimes after:

http://fallout.wikia.com/wiki/Come_Fly_With_Me#Corrupt_save_files

Although I think that was soon after the release of the original FNV, so you would hope it's been fixed by one of the patches since then.

I never had any issues with myself either. Maybe we were just lucky.