I would like to use a Browning M2 heavy machine gun packed with .50 cal depleted uranium ammo. I wish that I will be able to construct something similar or at least a light machine gun.

I have always wondered why hasn't there been any depleted uranium ammo in New Vegas because the game is packed with barrels filled with depleted radioactive material

The browning M2 was one of my favorite guns to use in WW2 games. A truely legendary weapon.

The glowing red crank lazer rifle has me intrigued so far. I believe with all the mods available and improved gunplay using guns is going to be a real joy!

Sawed off shotgun, All American, That Gun, This Machine, and Ratslayer so er... basically my current load-out in NV

EDIT: Addendum, Real life weapons I'd love to see in Fallout 4; Chiappa Triple Threat, Mateba Model 6 Unica Autorevolver (in .44 magnum), AK-47, AR-15, and any type of Mosin-Nagant.

EDIT2: And as if it was planned that way,one of my favourite gun channels on youtube does another video witth the Chiappa: https://www.youtube.com/watch?v=sI3x30iamHc

Lever action .20 gauge with a full tube of .20 gauge buckshot magnums.

Even though buckshot in all its forms seems to be a little underpowered.

A Tommy Gun, whether it is the authentic real life model or a gun that comes as close to possible to a Tommy Gun.

The latest concept art Bethesda released themselves shows that the engine looks to support a Chicago Typewriter style Thompson foregrip.

I'm really excited to see how I can customize the double barrel shotgun and .44 revolver. I'm also hoping I can make some form of Anti-Tank Rifle.

Springfield Sniper Rifle or M1 Garand

I doubt its in the game but there is a possibility one may be a

Time dilation grenade - freeze everyone in radius in a little bubble for a few seconds whilst you run away or sneak past or fire a load of shots that hit them all at once when the field collapses

Compound bow. And loads of other bows

Kukri machete. Or two.

Karabiner 98k

Pretty much every gun made by Heckler & Koch and FN Herstal.

Springfield Sniper Rifle or M1 Garand

These ^^^^

M1 Garand, fine rifle that is.

I think every post-apocalyptic game needs a AK. It should be a requirement in my book.

Every wasteland needs AK. Fine rifle, you shoot with many magazine of cartridge, you leave it in sand hell and it still work fine centuries after.

Rocket propelled fishystick launcher.

An Anti-Materiel Rifle.

I'd like a bow, I feel like a bow would be cool and we know they can do archery just look at skyrim.

Obviously with everyone using guns a bow would be strange, but for a stealth build it would be great.

I want the super sledgehammer to be back in Fallout 4. I don't know if it is currently.

It would be my primary weapon of choice though if it is.

This, my favorite from FNV.

Also the Bozar, like the overkill version found in Fallout 2.

For fun I'll probably see if there isn't a way to modify the laser musket into a waist-braced hand-powered gatling laser. Otherwise, probably gonna do whateve rI can to make an interesting-looking semi-auto marksman rifle or similar

Some sort of rusty pipe

1. Gauss rifle
2. Long range microwave gun that can blow up heads

Ooh I'll second this! Would go great with a concept for a character I've got in my head!

a lever-action carbine.

Railgun

Railway rifle.... and hopefully, a way to customize it into a railway sniper rifle

Wouldn't the awesome steam whistle give away your position? Lol

I love the Railway Rifle. The good old decapitator.