Mostly though, I think the Vault Experiments are a pretty stupid retcon based off of only 2 lines in Fallout 2 (one from the President and one on a computer terminal) and then taken and run into the end-zone by Chris Avellone in the Fallout Bible. The things that are considered official experiments are stupid. Penny Arcade's Fallout strip of one guy and a crate of puppets is considered canon?! I love Penny Arcade, but what the hell? Men, women, and one panther? One man and a 1000 women? Jesus, was the Vault-Tec CEO an 8-year old child?
Remember that the Fallout series has a strong element of satire/black comedy running throughout. It was more subtle in FO3 but it was still there. Not every element of the story is meant to be taken seriously. The vault experiment is intended to provoke a "dude, WTF?" response. It's one-half shout out to "Dr Strangelove" (particularly the last scene) and one half commentary on the military-industrial complex and bloated government bureaucracies.