Nope, but that's the only consequence (aside from bugs, of course) that I plan to reload my save for. Whether I mess up a quest, get expelled from a faction, or get caught murdering, I don't plan on reloading any saves.
One of the lighter variations that people do is, instead of scraping the character when you die, you go back to the last save you made when you slept at an Inn. So, regardless of where you've gone or what you did, if you die you go back to when you last had a good rest and pretend it was a dream. Failing quests or making a non-fatal mistake is not grounds for reload.
The same idea is there, to challenge you and make you cautious about encounters because dying will undo all the stuff you've done recently, but you don't have to start over from the beginning.