I keep changing my darn mind. I'm fairly certain I'll go the organic route, starting off mainly working on Sneak to gather materials to do crafting of all types: Alchemy/Blacksmithing/Enchanting and just "fall" into the quests as they come, but honestly I keep changing my mind on main weapon (dagger vs s/b vs bow), guild (fighter vs thief vs w/e), etc.
There's just so many good choices. It's somewhat painfully good.