You have chosen a somewhat hard road since fists can't be poisoned or enchanted and do limited damage. So. . . you need to get very fluent in what you have going for you:
1. Damage fatigue. Use spells to augment the effects of your fists. You want to get your opponent on the ground so you can pummel him.
2. Poison. Try to use a bow and start fights from distance with a poisoned arrow. Naturally, one of the effects you might want to work into your poisons for an approaching arrow-shot foe would be damage fatigue.
3. Consider conjuration or illusion to help with crowd control.