Huzzah! :foodndrink: Thank you, finally some sense... :shakehead:
That's not sense, because that's not how it worked. If you're in Skingrad, NPC's in Cheydinhal won't actually be walking around going about their business, because you're not in Cheydinhal. However, when you do enter Cheydinhal, the game will check where that NPC is supposed to be at the time and teleport them there.
I'm assuming that's how it will work in Skyrim as well. So therefore NPC's can't be killed by something if you're not somewhat near them.