Well, going by Betheda's track record, while I don't expect the PC version to get its own interface or anything like that, I expect a similar level of PC support to Oblivion, at least. Which is to say, while it doesn't take full advantage of the benefits of PCs, it does play alright on the platform. I've never once felt while playing Oblivion that I really don't want to play this game on PC, and I don't expect to with Skyrim either.
Well you'll be happy to know that the PC version will be getting it's own specific UI overhaul. But yes, I expect them to do a more Oblivion style change then Fallout 3 change. Oblivion looked worlds better on the PC than the 360 but fallout 3 looked barely better on the PC than the 360.