Not really happy on a PC at all, as a first reaction.
It seems, that somebody at Bethesda thinks, that a PC is just another gaming console.
Options for graphics resolutions have been narrowed down, the main menu has been made even more console-like, which I did not think was possible. It is unclear, whether the DLCs can be toggled. The entire mod management system seems heavily geared toward consoles and Bethesda.net. Perhaps other mods may also be used, but that is not immediately clear. I sure hope they haven't pulled a fast one on us.
The immediate first impression is strongly negative. Well, the graphics are better, but I was overwhelmed by the unexpected changes in the main menu system.
Perhaps all may not be that bad, but we shall see, I am not too trusting at the moment. I may have to sleep on this, and look at it more closely later.
Hmm. Now there is a Mods folder, which is separate from the Data folder, DLCs still have separate esm files, but all the textures and meshes are in sets of numbered bsa files, not DLC-specific ones. I really can't understand Bethesda's reasons for hiding and embargoing all the information about what changes they may have done to the setup, as this immediately raises more questions than it answers.