When you tell Elder Lyons about Vault 87 being the source of Super Mutants, he doesn't seem to give a damn, we assume he sends in a squad after the events of FO3.
He seemed to be interested to me...when you tell him about Vault 87 then ask him if he has any insight about the mutants he cracks that you've learned more about them in the few weeks you have been out of the Vault than they had in the last twenty years so perhaps they should be asking you that question. The War with the Enclave was the bigger concern at the time. During BS the Brotherhood does establish a presence in that area for the first time by driving Talon Company out of thier HQ at Fort Bannister (well, OK...watching you do it.). Leading the Scourge of Vault 87 would have been a good DLC....breaking the back of the mutant threat would give the BOS precious breathing room to rebuild thier numbers (and properly train thier recruits) and consolidate thier victories.