I had lots of troubles to get game working at all. It was totally unplayable with constant crashes and i wasnt able to fast travel at all. Game crashed back to desktop everytime. I tried everything. Finally I read an old post about Fallout 3 crashes caused by Asus GamerOSD. I uninstalled it and now game it working like a dream. So all of you with Asus motherboard and are struggling with crashes, check if you have Asus GamerOSD in you computer and uninstal it. Hopefully that will solve your problems as it did for me.