I'm not aware of any mod that does exactly what you're looking for, but the mods on Tarnsman's http://www.mwmythicmods.com/realism.htm offer some good alternatives. Example:
For example- mods that make containers either empty or with minimal stuff in it.
HotFusion's http://www.elricm.com/nuke/html/modules.php?op=modload&name=Downloads&file=index&req=viewdownloaddetails&lid=92 adjusts the leveled lists in such a way that valuable items are rarer in containers and only appear at higher levels.
Tarnsman's http://www.elricm.com/nuke/html/modules.php?op=modload&name=Downloads&file=index&req=viewdownloaddetails&lid=886 gives ownership to all of the outside containers in the cities, so you will think twice before looting them.
All in all, the mods featured on this page will make your game more challenging and (hopefully) more interesting.