(Don't lock this please, as this discussion isn't only related to Fallout 4 but future Fallout games as well and just fans opinions of what they dislike personally...kinda the opposite of the 'Offical Thread'.)
This thread is different, what aspect/s(anything) would totally drive you bonkers and make you extremely dislike it or refuse to play it? Removal of certain Fallout-mainstay's, addition of new elements, locations you never want to see, etc.?