Things like network hiccups, system freezes, damaged hardware, power outages/surges, etc are what'll increase the chances of file corruption.
Is that for active files only?
So if for any file you don't have the MD5 info on the original version/copy, is there any way you can try to "test" if a file is corrupted?
Applications may be unable to run, but for images, videos and raw audio, is there any way to probe for signs of corruption?