So far I've been taking
Disadvantages:
Forbidden Weapons: All except Longblades
Critical Weakness: Poison (apparently there's only one enemy who can poison you)
All starting skills reduced to 5%
Advantages:
Regenerate Spell Points
Increased Magery 3x INT
From my limited play experience (farthest I've got is the end of level 1 (bug prevented passage to level 2)), regenerate health is unnecessary if you have regenerate spell points and restore health spell. Is that true for later levels?
Any other disadvantages will low drawbacks?
Are there any other advantages worth taking? Athleticism? Adrenaline Rush?