Many keys are combined in silly ways (bash/grenade) or do too many things (tab has three different functions in the same part of the construction menu). That's just lazy, half-done, phoned-in console porting.
Blocking a chunk of the keyboard from rebinding isn't lazy, it's deliberate, and it's a mistake they had to fix when they released Skyrim, and they did it again.
Also, there are problems with AHK, I rebound the VATS key and it now only works in construction areas. Simple one-key-for-another rebind, nothing fancy.
As far as adapting, I wish console designers would "adapt" a controller with a few more buttons so most new games aren't crippled with the "everything button" disease.
edit: Also, this is an example of why game reviews are useless, unless someone can point out the dozens of reviews I missed that pointed out the crippled PC port interface. I mean, I figured out this problem before I even created a character.