the vault suits are the only upgradeable clothing (that still leave all slots open for armor) and end up with quite a bit of energy and rad resistance. so in tern I tend to run with combat armor to give me a good bit of all resistances.
that said it does get tiring wearing the same clothes all the time, so at the moment my girl is running around in a white t-shirt, blue jeans, and base combat armor legs (the increase her run speed by 20% and sneak speed by a bit, as well as being stealth coated
) though I play a very sneaky assassin so less weight is good and lack of resistances is not terribly noticed unless things go bad (they usually don't
)