I would venture to guess that Dragon Age was the biggest RPG since Oblivion, and I think there are many things in that game that could be added to Skyrim. For one, the cutscenes were great and the story unfolded according to choices I made.
I think Skyrim will also be filled with DLC, which is nothing new to the TES series, but the way Dragon Age did it with ingame advertising is something we might see in Skyrim. This is an evolution I do not wish to see in any TES games, but I think it's coming.
Fallout 3 introduced VATS, which might be cool to have in Skyrim for ranged attacks. Area specific damage would be great.