Hmm...I'm increasingly thinking that I should put together a "base install" that doesn't include any of the extended quests, but just gives an improved vanilla experience. Then I can tack the various quests on top of that install.
Hahaaa!!! It is interesting that you say this. I came to the exactly same conclusion a short while ago when I decided to take up OB for one more round. I used to have a full monty FCOM install which on the one hand I quite liked at the time, but on the other hand it was so stressful and always a bit crash prone. And I never got round to playing all the installed extra quest mods. I eventually bailed out at level 22 or so.
So this time I just have vanilla (and SI) and MMM as the backbone, plus some content mods (Cobl, Wepon among them) and basically only Integration - TSL as a major quest mod that I want to do, finally!! The main fighting changes are LAME and Duke Patrick. In the background of course there is OBSE and all those related plugins, plus Dark Darnified UI. Textures I use Bomret, bodies I just have vanilla at this time. Cosmetics are only Cobl Cosmetics and what comes with RBP, nothing too fancy.
The advantage of vanilla is that compatibilty is usually best. The "bandits in glass armour" annoyance I try to counter with Better Leveled Lists. I post my current Modlist for your reference.
Spoiler 00 Oblivion.esm01 All Natural Base.esm [Version 1.3.2]02 Cobl Main.esm [Version 1.73]03 Harvest[Containers].esm04 Mart's Monster Mod.esm [Version 3.7b3p3]05 Armamentarium.esm [Version 1.35]06 Artifacts.esm07 BetterMusicSystem.esm08 RealisticLeveling.esm** Cobl Races TNR.esp [Version 1.53]** Cobl Races TNR SI.esp [Version 1.53]09 Unofficial Oblivion Patch.esp [Version 3.4.0]0A DLCShiveringIsles.esp0B Unofficial Shivering Isles Patch.esp [Version 1.5.0]++ LoadingScreens.esp0C LoadingScreensAddOn.esp** LoadingScreensSI.esp0D All Natural.esp [Version 1.33]0E All Natural - SI.esp [Version 1.3.2]++ All Natural - MMM Patch.esp [Version 1.3]++ phinix-waterfix.esp0F All Natural - Real Lights.esp [Version 1.3.2]10 BAKAdventurerTorch.esp++ Item interchange - Extraction.esp [Version 0.78]11 BetterMusicSystem(SI).esp [Version 1.0]12 P1DseeYouSleep.esp13 VAs Better Gold with no Menu Icon.esp14 Enhanced Economy.esp [Version 5.4.3]15 BookTrackerOBSE.esp16 DarNifiedUI Config Addon.esp17 QZ Easy Menus.esp18 Streamline 3.1.esp19 Map Marker Overhaul.esp [Version 3.9.3]1A Map Marker Overhaul - SI additions.esp [Version 3.9.3]1B Enhanced Hotkeys.esp [Version 2.3.1]1C Adonnays Classical Weaponry.esp1D Adonnays Elven Weaponry.esp1E Adonnays Elven Weaponry for NPCs.esp1F ClassyClothingCompendium.esp++ CSR - Golden Saint.esp20 Weapon Expansion Pack for Oblivion Nthusiasts.esp [Version 1.03]21 Cobl Glue.esp [Version 1.73]22 Cobl Si.esp [Version 1.63]++ Cobl Tweaks.esp [Version 1.73]++ CSR - Fine Iron.esp++ ArmamentariumLL.esp [Version 1.35]++ ArmamentariumLLMagic.esp [Version 1.35]23 ArmamentariumArtifacts.esp [Version 1.35]++ ArmamentariumLLArmaVendor.esp [Version 1.35]++ Adonnays Elven Weaponry for NPCs - Armamentarium piggyback.esp++ Harvest[Containers] - Vanilla.esp++ Harvest[Containers] - SI.esp24 Mart's Monster Mod.esp [Version 3.7b3p3]++ Mart's Monster Mod - Shivering Isles.esp [Version 3.7b3p3]25 Mart's Monster Mod - Additional Enemy NPC Vars.esp [Version 3.7b3p3]++ Mart's Monster Mod - Diverse Imperial Armor.esp [Version 3.7b3p]++ Mart's Monster Mod - Looting NPCs & Creatures.esp [Version 3.7b3p3]++ Mart's Monster Mod - No Bone Loot.esp [Version 3.7b3p3]++ Mart's Monster Mod - No Uberhulks.esp [Version 3.7b3p3]26 Mart's Monster Mod - Dungeons of MMM.esp [Version 3.7b3p3]27 Mart's Monster Mod - More Wilderness Life.esp [Version 3.7b3p3]28 Mart's Monster Mod - City Defences.esp [Version 3.7b3p3]29 Mart's Monster Mod - Farm Animals.esp [Version 3.7b3p3]2A Mart's Monster Mod - Diverse WaterLife.esp [Version 3.7b3p3]++ MMM-Cobl.esp [Version 1.73]2B Artifacts.esp++ Artifacts - ArmaCompleteAddon.esp [Version 1.0]2C Knights.esp2D Knights - Unofficial Patch.esp [Version 1.1.2]++ Mart's Monster Mod - Knights.esp [Version 3.7b3p3]2E Salmo the Baker, Cobl.esp [Version 3.08]2F Harvest [Flora].esp [Version 3.0.0]++ Harvest [Flora] - Shivering Isles.esp [Version 3.0.0]++ Betterleveledlists.esp30 phinix_portable_tent.esp31 HUD Status Bars.esp [Version 5.3.2]32 DS Less Predictable Respawn.esp [Version 1.1]33 DS Portable Sorters.esp [Version 1.3]34 Dungeon Actors Have Torches 1.6 DT.esp35 Exterior Actors Have Torches 1.32 DT.esp36 PersuasionOverhaul.esp [Version 1.43]++ Respawning Ore Veins.esp37 ReneerNPCNameMod.esp38 Respawning Varla & Welkynd Stones.esp39 Toggleable Quantity Prompt.esp [Version 3.2.0]++ Enhanced Economy - House prices.esp [Version 5.4.3]3A Quest Award Leveller.esp++ Quest Award Leveller - Knights of the Nine.esp++ RealisticForceHigh.esp++ RealisticMagicForceMedium.esp3B RefScope.esp [Version 2.1.2]3C Harvester.esp3D Lightweight Potions.esp [Version 1.1]3E Denock Arrows.esp3F Duke Patricks - Near Miss Magic And Arrows Alert The Target.esp [Version 7.1]40 Duke Patricks - Actors Can Miss Now.esp41 Duke Patricks - Melee Combat NO RECOIL.esp [Version 5.8.3]42 immersive_caves_auto.esp** Cava Obscura - Cyrodiil.esp** Cava Obscura - SI.esp** Cava Obscura - Filter Patch For Mods.esp++ Item interchange - Placement.esp [Version 0.78]43 bgBalancingEVCore.esp [Version 10.52EV-D]++ Mart's Monster Mod - Resized Races.esp [Version 3.7b3p3]** Better Redguard v2.esp44 bgMagicEV.esp [Version 1.7EV]++ bgMagicSpellTomes_for_WryeBash.esp [Version 1.68EV]++ bgMagicItemSigil.esp [Version 1.68EV]++ bgMagicEVStartspells.esp [Version 1.68EV]45 bgMagicBonus.esp [Version 1.7EV]++ bgMagicEVAddEnVar.esp [Version 1.68EV]46 bgMagicEVPaperChase.esp [Version 1.68EV]++ bgMagicAlchemy.esp [Version 1.57]++ bgMagicPotionNumberSoulGemValue.esp [Version 1.68UV]++ bgBalancingOptionalLessHealth.esp [Version 10.0UV-U]++ bgBalancingEVOptionalClasses.esp [Version 9.0EV-U]++ bgBalancingEVOptionalBetterRedguards.esp47 bgBalancingEVLAMEAddition.esp [Version 10.51EV-D]++ bgBalancingEVLAMEGlue.esp [Version 10.0EV-D1.62EV]++ bgBalancingEVOptionalSeamReducerHighElfFix.esp [Version 10.0EV-D]48 bgIntegrationEV.esp [Version 1.0b]++ Integration faces revamped.esp49 Automatic Timescale.esp [Version 1.1.1]** bgMagicEVShader.esp [Version 1.7EV]++ bgMagicShaderLifeDetect.esp [Version 1.68]4A kuerteeDetectLifeEffectNightEyeShader.esp++ bgMagicLightningbolt.esp++ CoreRandmonClothing4Npcs.esp++ Harvest Containers Filter patch for mods.esp [Version 1.00]** All Natural - Indoor Weather Filter For Mods.esp [Version 1.3.2]4B Clintmichs Beautiful Market District MakeOver v1.4.esp4C Ferryboats.esp4D Bashed Patch, 0.esp4E DynamicLeveledLists.esp
It is not fully populated yet, some "basics" mods are still missing like Tamriel Travellers. But I have a policy of only installing in small batches. Non-core at this time I consider 1F, 3C, 4B and 4C.
I really like mods that work on the leveled lists: Items interchange, Better LL's, CoreRandmon, and DLL by Leviathan which is really great conceptually and how he actually implemented it (GUI).