Boone, armed with a sniper rifle, 200 AP .308 shells, five grenades, and the lowest tier BoS power armor (which he can wear as soon as you find some, no training required) solo'd the entirety of Camp McCarran without taking any noticeable damage at all. I simply started up the fight and watched him go to town. He cleared the train station/command post in under two minutes without taking a single point of damage. I led him outside and he mopped up the entire camp with no fuss. The yard was a mess of dismembered limbs, bodies buried under a sea of arms and heads.
I'm pretty sure that Boone could literally destroy the entire world before needing to take a nap. A hail of warheads reducing the nation to a nuclear wasteland has nothing on the destruction that a single Boone will unleash upon the planet.