No, they don't.
They've been in every Fallout game.
Fallout 1 they were avoidable but they were one of the bigger factions in the game.
Fallout 2 they had presence but not a lot to do.
Tactics revolves around them.
The Burned Game revolves around them.
Fallout 3 you're forced to team up with them.
In New Vegas you're forced to deal with them 3 out of 4 paths.
The pitt, O:A and Broken Steel had ties to them.
And Dead Money had ties to them.
They really don't need "anything"... At all..