One of the main problems with Tactics is not the events, but the fact that it abandoned all of the retro elements of previous Fallouts. It had none of the 1950s retrofuturism of previous games (and of Fallout 3). Nearly all of the weapons were either modern or from the WW2 era, instead of the weapons from Fallout's alternate future (although Fallout 2 is also guilty of that to a lesser extent).
There is now evidence with Fallout 3 that the Enclave survived in many places. Who is to say that the Enclave did not have other bases in the midwest, experimenting on Deathclaws with FEV?
The problem is not that they experimented with deathclaws elsewhere. The problem is that Tactics takes place before the Enclave even started to experiment with deathclaws.
The brotherhood timeline is fine. Anyone that says differently needs to put their taped up nerd glasses away.
They are said to come from a "military vault", which is not true.
Also, the developers of Tactics confused the Vault Boy with Pip-Boy.
I do not have a link but if you are really curious pm Ausir and he can hook you up with more info. One of his post on the topic was where I got the answer from when I was curious.
I asked Emil and he confirmed that they consider the major, high-level events of Tactics canon.