So a quick run down of the things I personally have encountered.
1. Modding the weathered 10mm causes game glitch
2. trying to enter the strip after a certain point in the game causes it to crash
3. sometimes weathered 10mm won't go into vats.
4. sometimes fast travel causes game to crash.
5. sometimes entering or exiting a building cause game to crash.
6. two to three straight hours of game play causes lag and eventual crash.
7. minor sound clipping on vats from time to time
8. voices don't always sync up with characters lips
9. depending on the location character can/has fall(en) through the ground.(see radio tower at mccaren)
10. sometimes character can walk through terrain ie: going up a mountain side only to become stuck in the terrain itself.
11. commonly seen low ground units stuck in the ground, radscorpions, nightstalkers...etc etc

well this is all I have encountered so far. If you have any too add to the list please do, I hope this actually helps bethesda in identifying the problems more efficiently.

On a side note if anyone from bethesda reads this I hope they post something about the advent of an update. it is greatly needed.

update: i found another glitch

when NPC's sit in a chair often times they sit off to the side of it.

Another issue I have come across is when using large weapons such as the mini gun a glitch occurs when putting the weapon away in that it doesn't disappear, instead it falls to the side and sticks to the characters hand. Also on the topic of mini guns a major glitch occurs when wearing it, the ammo pack often falls off and hangs in space, this occurs several times though the ammo pack also remains on the characters back. Another issue is that the mini gun will not always fire correctly. At point blank range the mini gun sound file activates and the ammo begins to drain along with a muzzle flash yet the barrels do not turn and the enemy accrues no damage. This weapon also has trouble going into and out of VATS.