If I press E on something like an ammo box the animation on it will play but no menus appear if I try to talk to someone they turn to face me then walk away if I press quick saving and quick loading also don't work and the audio for bullets doesn't play sometimes pressing ESC will bring up the menu and when I go back into the game its fine but then it screws up and the menu doesn't always fix that there was a minor delay when I played on xbox but this is unplayable is there a way to fix it?

Your on pc im guessing and the ammo inventory box is not showing up right? Also did you install the game correctly, because sometimes this happens from the files being misplaced and put in to the wrong folders instead of the right folders. All I know if your menus isn't showing, try tm in console. But if it's a different thing let me know more detail about this and I may be able to help you out some more and fix this problem for you.

Its not the install it works fine when in doc mitchells house I just went to test it and opening a delivery box? ( big blue box outside the general store in goodsprings) causes me to ctd thenI walked near to the general store and I got another ctd. the ammo box shows up its just no menus appear when pressing E its like lag because sometimes it just takes like 30 seconds to appear and sometimes it wont at all.

Is it a delay between box animation and actually seeing the contents or do you never actually get to see the inventory? Are you running any mods.

All animations play instantly its the inventory of crates and anything like that and its the same for dialogue yeah im running a lot of mods but it was fine before so I don't see why it would happen now is there any kind of program I can use to get the list of mods im running instead of typing it all out since there is over 100 then I can post what im using

Ah I found the problem my game is possessed by the devil textures randomly disappear or mix with other textures mods that work fine suddenly don't well time to get a bible and some holly water.