After Clavicus Vile has asked you to give him the sword, the game will crash, whether you opt to return it to him or keep it for yourself. The glitch is related to the dog statue that appears in your inventory after you receive the quest, through which the Hound of Clavicus Vile speaks to you and tries to convince you not to complete the quest.
It just seemed that I load a saved game, wherever I was, walk for about 2 seconds, and wherever I was, the game would freeze. But I fixed it by quickly fast travelling from city to city, and the statue went from my inventory.
I am running into the same problem and its very annoying since I really was hoping to do all the quests in the game. Does the fast travelling thing work on the XBOX 360 version of the game as well. Or, is there another way to finish this quest? It won't let me drop, sell or store the silly little dog statue, which is also very annoying.
Any and all help will be greatly appreciated.
P.S. This is my first time playing this game. That's why I want to do all the quests in the game.