like lore wise and stuff? itd be a pretty weird transformation but i thought Argonians were immune to disease, even though u can catch vampireism in oblivion so idk

Yes. It was possible in Bloodmoon, the Morrowind expansion.

If the argonian in question gets hit with something that weakens its immunity, it's possible. Very unlikely, but possible.

Can go further back to Daggerfall; Argonian can become werewolf/wereboar in that game.