TL;DR I find FO4's combat wholly unsatisfying and explain why.
So, after taking some time to cool off so I wouldn't get banned from the forums, I tried going back to FO4 and attempted to just enjoy the combat. And failed. Here is why:
I already knew this from day one, but the mouse controls are terrible. Fortunately, some folks found fixes for the more egregious issues (disparate vertical and horizontal sensitivities) via .ini tweaks. But some issues still linger.
Many weapons, particularly the two-handed kind, feel like they're made of rubber, not just when moving the viewpoint in hip-fire mode, but also when aiming down the sights (iron or reflex). In the case of certain weapons, the hunting rifle being the worst offender, it makes the iron sights practically unusable, because http://gfycat.com/TightCircularGermanshorthairedpointer , making aiming at moving targets nearly impossible. Did anyone at any point during development attempt to play with the iron sights on the hunting rifle for more than five minutes? Also, http://i.imgur.com/lnPS98N.png on my screen (HD). Two pixels! Are you flipping kidding me?
You went in a completely different direction when designing the iron sights for the pipe weapons; http://i.imgur.com/TTHArSF.png my cat swiped at them once while I was playing (well ok he just did that crazy head-tracking thing). Those gargantuan sights might be fine in Jurassic Park, or on a shotgun (and say, why is there no pipe shotgun?), but NOT when you need any kind of precision.
Bring on the reflex sights, am I right? Yes, and no. For starters, not all weapons have access to the dot reflex sight: laser and plasma weapons inexplicably only have access to the circle variant, which is pretty crappy for single-shot 'rifles' as you want pin-point precision; the circle is better for shotguns and fully automatic weapons so you don't lose track of the sight. On top of that, the rubbery syndrome also makes an appearance here, bringing the point of aim close to the sight's frame even when moving the mouse slowly, obscuring the target and making quick shots difficult. Also, http://gfycat.com/GrayCloseCrab. I won't even bring up the 'reflex sights' for the pipe weapons.
Scopes! Surely they didn't mess up the scopes? The only good thing scopes have (and it's a very, very good thing) is that they completely bypass the rubbery syndrome. Unfortunately, the hairs are pixel-thin, making them really hard to spot during heavy firefights, and in their infinite wisdom, the designers decided to add a bunch of extraneous crap to them to further distract you from the point of aim. So fine, they're at least usable, but not very enjoyable unless you're sneaking and have all the time in the world to aim. Oh, and the background isn't too dark. Unless you're using a night-vision scope. And the background isn't too bright... Because there is no way to toggle the night-vision...
And why, pray tell, do sights / scopes affect a weapon's accuracy? Aiming with iron sights is hard enough without you making the gun magically less accurate. Why punish someone for using them? I can understand affecting the VATS accuracy for balance reasons, but not sighted accuracy for Atom's sake. In fact, you should punish players slightly for attaching heavier stuff onto their weapons by worsening hip-fire aim, scope sway, etc.. No, getting a player a few pounds closer to his carry weight isn't what I call punishing :/.
Then there is the issue with ammo. With a couple ranks of Scrounger, by the time I had found a .50 cal receiver, I had over 600 cartridges, just found in random containers. I'd find 12-20 in one go. And yet, finding .44 ammo elicited the same emotions as chancing upon a duct tape multi-pack. So much for my idea of having a revolver as a sidearm (and why does the revolver not have access to glow sights by the way? Why is there no consistency in the weapon mods?). Shotgun shells were also very rare. You'd think they'd be as common as Brahmin dung, but you'd be wrong. At some point in the 210 years our character was frozen, a broken down army truck filled with .50 cal cartridges must have been raided and its contents distributed equitably across the commonwealth for everyone's high-caliber enjoyment. Even though you can count the number of commonwealth guys with .50 cal weapons on a single, slightly mutated hand.
I won't talk about the weapons' actual killing power because everyone has already gone through that pretty well. And I won't touch on the magical legendary properties because, well, that's what the cool-off period was for. I'm over that. I am. I am.
Finally, I leave you with this http://i.imgur.com/qeFed6c.jpg. I think it doubles as a shield, but I'm not certain. Maybe it's one of them legendary thingies I keep hearing about?
Oh, and just so you don't think I'm a bitter hater, I do think that the shooting is responsive and impactful, and recoil works pretty well (don't like the auto-recovery but that's just a personal thing). This is usually what new shooters get wrong, so it was at least nice to see that they nailed that side of things.