Not sure, but it seems to happen more after dialogues/fights/pip-boy use...
I've un/re installed, fiddled with graphics settings, assigned a new key, googled for hours, etc
I have the Italian version, patched to 1.7.03 (although THAT wasn't easy to do, with missing xlive.dll error - which i eventually "fixed" with a windows live disabler btw)
I have an Acer laptop 5742 G / 4GB DDR3 / IntelCore i5 / NVIDIA GeForce 540M, everything updated i think...
Answers hugely appreciated as i've been fiddling with this and other Fallout 3 issues for too many nights and i don't want to stick it on a shelf to gather dust !