I've been playing a character for around 20 hours. I did not modify my mod list the entire time besides uninstalling NMC's textures.

Today, I went on and upon fast travelling, I cannot select items in my inventory. When I talk to NPCs, when I right click I can't skip dialogue and I can't select dialogue options either.

Here is my load order

FIrst thing I would do is see if this happens in a previous save. I would also try a new game. Not that you have to start a new game. Just for testing.