It seems after the most recent patch, I am not able to complete any quest that requires picking items up or dropping them off. They are all broken. The following quests are broken:

1) Here There Be Monsters - Admiral will not speak when spoken to

2) Out of the Fire AND The Slog: Greenskins - Preston gave me the quests, and the farms appeared in my map, but no markers appear when making the quest active and talking to the settlers does not trigger them

3) Long Time Coming - game won't register that I have picked up all Eddie Winter Holotapes

4) Moe Cronin Miscellaneous Quest - won't register that I have picked up the baseball, glove and card; map markers stay in place despite picking quest items up

5) Public Knowledge - despite returning the overdue book, the marker remains active on the book return unit; cleared the library and got prompted to return to Daisy, but upon return, she only asks if the job is done, likely because the markers are still up for returning the book (I returned all my overdue books, just to make sure I returned hers, too)

6) Ghoul Problem at Nordhagen Beach - went to settlement, but no one will prompt the quest; no map marker when quest is active

I'm sure there are many more broken quests. This is infuriating, since I have over 150 hours into the game, and now it looks like it's totally broken. Has anyone had a similar experience? Any fixes?

Trying not to read your post because of spoilers. This looks like something you should be asking on the technical issues forum, not the general discussion one. Good luck, though- I would be pissed if I was in that situation.