This is the easiest problem Bethesda has to solve.
Make the game for hardcoe AND casual gamers. hardcoe mode in Fallout New Vegas was a great idea by Obsidian, but it was clearly a late-in-development idea that wasn't properly thought out. If Bethesda was to think long and hard about a hardcoe mode, I'm sure they could come up with some really great ideas.
A couple examples of possible hardcoe mode features:
1. In hardcoe mode you can't fast travel. This would require the adding of Morrowind style fast travel nodes/spells.
2. No magic quest arrow. This would require quest locations to be described better by quest givers.
Just a couple examples that seem to be hot topics for the more hardcoe. If Bethesda added such a mode, it would solve so many issues and make everyone happy. Its very very possible for them to do it, its just a matter of how much they want to do for the hardcoe crowd. I'm going to guess they aren't going to do anything for us to be honest.
Great idea - here's how to do it.
STEP ONE. Don't fast travel. (My first playthrough for FNV lasted 160+hrs and I only succumbed to the temptation to fast travel twice, in order to rehire companions for their quests.)
STEP TWO. Don't activate the quest for whatever you're looking for. (The quest marker will disappear. This works for me with Oblivion.)
If you explore all of the cells on the map over time (much easier if you choose not to fast travel), eventually you will find all of the locations for the various quests you have started. Sure, some of the locations will be more difficult to find, but you will get to them eventually. Many quest locations will be relatively easy to find even with crappy/vague/nonexistent instructions from the NPC.