For most of my chars i never have more then 1 in charisma and have at least 6 in everything but int which i often put at 9 since i go get the int bobblehead pretty much right after getting outta the vault, then get educated at level 4 to up the number of skill points per level to 23 but that might just be because i like to get as strong as possible as quickly as possible.
For perks you could get
fortune finder to find more caps and
scrounger to find more ammo,
gunslinger to up hit chance of single handed guns in vats and
commando which does the same for two handed guns, probaly get
action boy/girl to get an extra 20-25 action points,
silent runner will make you quiet even when running in sneak mode although im not sure if armor weight still plays a role in the chance of getting detected and it'll add 10 to your sneak but you need 50 or 60 sneak to get it first,
cyborg will up your damage protection by 10% and add 10 to your energy weapons skill but it needs i think 60 in sceince and medicine it'll also add to poison and rad defense as well i think.