In Skyrim, I could barely care about what happen to any factions or anyone, so siding with one vs the other wasn't too hard because I could care less about them. All the NPCs are pretty static, but in Fallout 4, the characters are a lot more interesting. It makes it tough to destroy the Brotherhood because there are good people like Haylen had a crush on Rhys, and she stands by Danse regardless of what happens. The Institute while appears to do heinous crimes have a lot of very nice people there. Allie is very nice and supportive, even Lawrence locked the food supply was because he cares about the place and wants Father to change his mind about the director. While I don't care about RR people, Deacon is a very cool guy to hang around. A lot of the characters are very memorable and they leave a big impression on my mind over many characters in Skyrim despite Skyrim being the game I logged in many many more hours.