after playing FNV 100's of times, still loving it, but getting bored with certain aspects (especially the DLC's) i discovered that the one-shot-kill .44 revolver from FO3 is still available and usable with console commands on PC.
sure, cheating is not for everyone, but for those who want to zip through Dead Money, et al, it really speeds things up.
once i get back to the Mohave, i usually toss it away.
i have me a love affair with my fully-modded 12.7 sub machine gun.