Obvious pure good vs evil.
Damsel in distress- and for some reason the damsel in distress is almost always held captive by a male villain.
Humans are the most important species ever trope.
Humans becoming something other than human is virtually ALWAYS portrayed as a bad thing.
Whenever humans are downtrodden or marginalized the chances of you having to play as one go up enormously.
Orcs are evil and elves are good (for some reason?).
Even if a game has lizard people, zombies, cat people, zombie people/etc/ for some reason you still usually have to be a human dwarf or elf anyways. When it comes to bipedal animal people, often the females of the species look more humanoid (The Elder Scrolls series avoids this trope though).
The storyline always has to have epic stakes, where the villains reign is always a global or multi planet issue.
Even though the protagonist may have amazing superpowers, the villains tend to usually be depicted as having more powerful weapons. (With I suppose Batman/Iron Man being the few exceptions).
People with glowing eyes, scars and spikes are far more likely to be depicted as villains.
The vast majority of zombie fiction is humans vs zombies, instead of the imo much more fascinating robots vs zombies or aliens vs zombies or werewolves vs zombies.
That's all just off the top of my head.