Late game I think the Riot Shotgun, LMG, Assault Carbine and Minigun smoke all Melee weapons close range.
So what is everyone elses thoughts. Am I just not giving Melee/Unarmed a chance? Or is Guns the best combat skill! Period.
That's because Chance's Knife is a very good weapon for some opponents and very bad for others, specially animals. For example, Knock-Knock with Super Slam don't need more than two blows to knockdown ANY enemy in the game, usually is in the first one, so give it a try.
If you want to clean Quarry Junction with a melee weapon this is the one (or a Chainsaw/Oh Baby!, but they are heavy to carry around)
If I'm using guns for close encounters I go with shotguns, but usually I prefer to spend some points in melee and use Fire Axe/Chainsaw/Knock-Knock/Oh, Baby! than spending two perks for working with shotguns.
You have to pick at least Shotgun Surgeon, otherwise shotguns are not good weapons in the long run, with the exception of a Riot Shotgun (but she needs at least 90 in guns to be a good weapon).
With Shotgun Surgeon and And Stay Back perks you don't need other weapons in the game, really, just craft some magnum rounds and switch accordling.