Just wanted to be clear, this is not about the setting, well, it kind of is, but not really.

Did Skyrim have any clues that point to where the series is going? If so, could they also be misdirection. Here is something I thought of just now: In Hob's Fall Cave in Skyrim, a group of Necromancers is trying to revive the Order of the Black Worm. the Necromancer Amulet being a part of the quest "Blood on the Ice" and then there is that ship in Solitude "Dainty Sload". Could these be subtle clues that point to Mannimarco, the King of Worms, and the Sload appearing in the next game, or perhaps to ESO?

You can take anything in the game and make clues out of it actually...

Isn't it obvious what the next plot will be? THE DWEMER HAVE RETURNED!!! *cue dramatic electro steam punk sounding ES theme song*

From Dagoth Ur and his sleeper cult, to Dagon's Daedra, to Alduin and the Dragon's to Molag Bal and the minions of Cold Harbour. It's gotta be an invasion!

No its not the Dwemer, its the return of Numidium..

I'm betting on "The Rise of the Mudcrabs." We've been getting clues to this for several games.