Here are some pointers that I use for dealing with collision meshes
1. Collision meshes (aka RootCollisionNodes) should be simplified versions of the original mesh
Not every tiny little detail needs to be in the collision mesh.
One exception to this may be landscape terrain. If you remove the detail, then the player or NPCs may bleed into the ground.
2. If the model is already simple, for example 2 triangles for a floor, then a collision mesh is not needed (see Morrowinds I\in_vs_pitfloor_01.nif).
Set the flags of NiNodes and NiTriShapes to Collision Detection "Triangles".
In NifSkope
A. Right Click on NiNode (click on triangles located in the "Block List" area to expand the tree structure or listing)
B. Select Flags
C. Select Collision Detection "Triangles" (be sure Hidden and Skin Influence are unchecked, only check these if needed)
D. Repeat above steps for all the NiNodes, and NiTrishapes.
E. Remove any RootCollisionNodes ( do the following or select the RootCollisionNode and press Ctrl+Del)
E1. Right click on RootCollisionNode
E2. Select Block
E3. Select Remove Branch
F. Save file
Some files use Collision Detection "Bounding Box" in their Flags. This appears to work as well, but "Bounding Boxes" are typically used for Creatures/NPCs.