As for me, this happened a long time ago. But I still remember it. I think it's my favourite combat in my whole playthrough with Fallout 1 and Fallout 2.
Fallout 2's New Reno spoilers ahead!
My character, an evil slaver/merc meets a woman in the Bishop's Casino, the headquarters of their mafia. This woman, none other than the Bishop's wife, seduces my character and invites him for "a glass of wine" in her private quarters. Jason Winston, my character, is also a six addict. He is known in New Reno for his role in advlt movies and the prosttutes know his name.
So, after getting done with the Bishop's wife, she falls asleep. In her sleep, she says the combination to the crimelord's safe, which I open and loot. But then, on my way out, I see a man in green with two armed guards waiting for me.
As soon as I cross the doorframe, the dialog between him and me goes in the line of :
"You!! What are you doing here!? Explain yourself! Now!"
"I..erm.. I banged your wife! Gotta run!"
Combat starts (Wohoo!). I painfully manage to take the Bishop and his two guards down with many stimpacks. But then I think : "Damn. The first floor is crowded with guards. How the hell am I getting out of this!?"
I decide to take two shot of Jet for more movement (Which got me addicted for the rest of the game), then I proceed downstairs. As soon as I'm on the first floor, 5 guards start shooting at me. I quickly run away, trying to evade the bullets, but 5 more guards attack me. Each turn, I have 10 guards trying to kill me. I use a stimpack at almost every turn to stay alive. When I finally manage to cross the entrance, the two doormen get their tommy guns and shoot me. That's 2 more guards.
I manage to get on the street and proceed to the exit grid when I notice that a prosttute, behind me, just got shot in the back by a bullet that missed me. At that moment, the tide of battle turns in my favor. With their friend dead, every single prosttute in the Central New Reno area get their knives and jump on Bishop's guards. Not only the prosttutes, but their pimps as well, who are equipped with guns.
To add to the battle, one of the pimp misses a guard and the bullet hits one of the casino's gamblers. Now, every gamblers in the casino attack the prosttutes and the pimps.
It was a real western in there, with bullets flying everywhere, prosttutes stabbing gamblers to death, the pimps getting shot or shooting the guards. Of course, I helped the prosttutes and their pimps. But, in the end, there was only a guard left, whom I killed.
The streets in front of Bishop's casino was filled with blood and bodies. So was the inside of the casino itself. The pimps' bodies were filled with Jet, so that was most useful. As for the rest, I spent days selling the loot I got from the Casino.