Just a thought, but given the details of the trailer (and previously leaked info) regarding a possible pre-war tutorial, would it not be feasible that we begin our journey at MIT as some kind of advisor? - edit: I am referring to the tutorial only, and not the main game - This would tie in with our suggested military background, and could even incorporate the character creation process - maybe the protagonist is silent until we have had an opportunity to select gender and other characteristics. It would also give us a relatively large indoor area to initially explore - as per vault 101 in Fallout 3 - and would be an excellent way to build up tension as news begins to spread about the outbreak of war.
Lets say, for example, that right in the middle of whatever meeting or discussion we are involved in, the air sirens start going crazy and we are quickly ushered out of the facility and into a nearby vertibird. Due to our important role, we are then transported across to the area of vault 111 (which is also near to the player's home as shown in the trailer), but instead of going straight into the vault we rush home to collect our family. We make our way towards the vault and arrive just as the bomb detonates (again, as per trailer).
Maybe we would be the only one allowed into the vault due to space limitations, and we would be forced (by military) to leave our family outside to perish. Or perhaps one or both of them are also saved, but die once inside the vault as a result of the nuclear explosion.
This would obviously require a number of locations that would need to be created as pre-war assets, some of which we saw in the trailer - Namely MIT itself (aka the Institute), Watertown, and the area in between the two. This would also prove interesting when we later revisit the Institute some 200 years later during the main quest after we awake from cryostasis inside the vault.